METFORMIN DURING ADULTHOOD CANNOT ATTENUATE THE HARMFUL EFFECTS OF NEONATAL OVERNUTRITION

Under- or overnutrition, during critical periods of development, lead to the development ofobesity and cardiometabolic dysfunction later in life rats that have been programmed forthe metabolic a litter reduction model. On day 1, all litters arestandardized 9 pups per dam on 3 after birth, were adjusted perdam small group (SL) NL remained with animals. At 70 days ofage, animals separated into 2 new groups: Saline (SAL) Metformin (MET). For12 days, SL treated daily saline, giving rise NL-SAL andSL-SAL groups, Met 100mg/kg/day, NL-MET SL-MET groups. The treatment ended at 82 age taken up 142days life. Body weight significantly higher compared to142 (p<0.0001), no significant difference relation treatment. And samewas observed glucose intolerance insulin resistance (p<0.0001). We canconclude short-term metformin did not attenuate metabolicdysfunction induced by neonatal overnutrition.